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compound; method of treating an amyloidosis in an individual; pharmaceutical composition; and method for treating a condition that is a selected member of memory loss, cognition loss and a combination thereof.
compound; method of treating an amyloidosis in an individual; pharmaceutical composition; and method for treating a condition that is a selected member of memory loss, cognition loss and a combination thereof.
In general, among other things, compounds of Formula I are provided: in which R11 is selected from the group consisting of benzylamino, N-methylbenzylamino, morpholino, thiomorpholino, pyrrolidino, etc.; R13 is selected from the group consisting of 3-(1-ethanol-2-yl)phenyl, 3-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, 2-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, etc.; and R12 and R14 are each independently hydrogen or alkyl. Methods of treatment are also provided.
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机译:通常,除其他外,提供式I的化合物:其中R11选自苄氨基,N-甲基苄氨基,吗啉代,硫代吗啉代,吡咯烷基等。 R13选自3-(1-乙醇-2-基)苯基,3-(1-ol-2,2,2-三氟乙-2-基)苯基,2-(1-ol-2 ,2,2-三氟乙-2-基)苯基等; R 12和R 14各自独立地为氢或烷基。还提供了治疗方法。
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