METHODS FOR USING A DNA EXPRESSION BUILDING; Use two or three DNA expression constructs; USING DNA EXPRESSION CONSTRUCTIONS FOR THE PRODUCTION OF A VACCINE FOR TREATMENT OF DISEASES OF LEISHMANIOSIS INFECTIONS; USING TWO OR THREE CONSTRUCTIONS FOR DNA EXPRESSION FOR PRODUCTION OF A VACCINE FOR TREATMENT OF DISEASES OF LEISHMANIOSIS INFECTIONS; DNA EXPRESSION CONSTRUCTIONS; AND VACCINE FOR TREATMENT OF DISEASES OF LEISHMANIOSIS INFECTIONS

摘要

"means for treating leishmaniasis infections". The invention relates to the use of a combination of DNA expression constructs for the manufacture of a medicament for immunization against leishmaniasis infections, as well as a corresponding vaccine. DNA expression constructs themselves are also an object of the invention. according to the invention, it is preferably intended that the p36 lack immunogenic antigen be used in combination with the leishmania infantum thiol-specific antioxidant protein antigen (tsa), the leishmania infantum kinetoplast membrane protein antigen ( kmp-11) and leishmania infantum glycoprotein antigen 63 (gp63), for the generation of an immune response. As plasmids for DNA expression constructs, expression construct plasmids may be used, and preferably the immunologically defined minimalist gene expression constructs (midge) according to the invention are used. Other DNA expression constructs according to the invention are used to produce a leishmaniasis disease vaccine and are part of a corresponding vaccine.