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PHARMACOKINETIC ANALYSIS METHOD, PHARMACOKINETIC ANALYSIS DEVICE, AND PROGRAM

机译:药代动力学分析方法,药代动力学分析装置和程序

摘要

The purpose of the present invention is to provide a pharmacokinetic analysis method and the like, whereby a pharmacokinetic change in a patient can be easily analyzed in response to a change in a physiological function of the patient. An individual pharmacokinetics calculation unit 21 calculates an individual pharmacokinetic value of a patient by using an entered physiological function of the patient and a mathematical model, and a population pharmacokinetics acquisition unit 25 obtains a population pharmacokinetic value of a population to which the patient belongs. A variation coefficient calculation unit 29 calculates a variation coefficient from the individual pharmacokinetic value and the population pharmacokinetic value. A change-in-population-pharmacokinetics acquisition unit 41 obtains a change in the average pharmacokinetic value of the population in response to the change in the entered physiological function. A change-in-patient-pharmacokinetics calculation unit 45 obtains, by taking advantage of the fact that the variation coefficient remains constant even when the physiological function has changed, a change in the individual pharmacokinetic value of the patient by using the change in the average pharmacokinetic value of the population and the variation coefficient.
机译:本发明的目的是提供一种药代动力学分析方法等,由此可以响应于患者的生理功能的变化而容易地分析患者的药代动力学变化。个体药代动力学计算单元21通过使用输入的患者的生理功能和数学模型来计算患者的个体药代动力学值,并且群体药代动力学获取单元25获得患者所属群体的群体药代动力学值。变异系数计算单元29根据个体药代动力学值和总体药代动力学值来计算变异系数。人群中药代动力学变化获取单元41响应于所输入的生理功能的变化来获得人群的平均药代动力学值的变化。利用患者的药代动力学变化计算单元45,即使生理功能发生变化,变异系数也保持恒定,从而利用平均值的变化来求出患者的个体药代动力学值的变化。人群的药代动力学值及其变异系数。

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