1 1 Once-daily fixed-dose combination bilayer tablet comprising cilostazol and angiotensin receptor blockers and manufacturing method thereof

摘要

The present invention relates to a once-daily oral composite bilayer tablet comprising cilostazol and angiotensin receptor blockers and a method for manufacturing the same. The bilayer tablet according to the present invention comprises a cilostazol sustained release layer and an angiotensin receptor blocker immediate release layer. In the cilostazol sustained release layer, a certain fixed dose of povidone K-90 and Eudragit RL or RS are used as a sustained releasing agent, so that a bilayer tablet comprising a fixed dose of cilostazol and angiotensin receptor blockers which can be taken orally once a day can be provided. Therefore, the tablet can be widely used as a customized composite formulation for elderly patients with ischemic complex vascular disease accompanied by hypertension and patients susceptible to diabetes, chronic cardiovascular disease and nephropathy, and can enhance convenience of medication and patient compliance.