ABAT GABA ANTISENSE OLIGONUCLEOTIDE FOR INHIBITING EXPRESSION OF GLIAL CELL SPECIFIC ABAT EXPRESSION VECTOR INCLUDING THE SAME AND METHOD OF SCREENING ANTISENSE OLIGONUCLEOTIDE FOR INDUCING GABA PRODUCTION

摘要

According to one example of the present invention, an antisense oligonucleotide for inhibiting the expression of glial cell-specific 4-aminobutyrate aminotransferase (ABAT) is provided. The antisense oligonucleotide is represented by any one of sequence numbers 1 to 3 and is characterized by binding in a complementary fashion to an mRNA of a gene encoding glial cell-specific ABAT. The antisense oligonucleotide of the present invention and an expression vector comprising the same can induce GABA formation in glial cells by inhibiting the expression of ABAT which breaks down GABA.