SINGLE-DOMAIN ANTIBODIES TO EBOLA VIRUS GP PROTEIN FOR IMMUNOTHERAPY OF EBOLA FEVER

摘要

FIELD: biotechnology.;SUBSTANCE: presented single-domain and oligomeric antibodies contain an antigen-binding amino acid sequence, selected from a group consisting of sequences SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, on the basis of which compositions, intended for the prevention and treatment of infection of mammals caused by Ebola virus, are created.;EFFECT: proposed antibodies bind to the GP protein of the Ebola virus and have a virus-neutralizing activity and protect against infection and development of the infection in vivo.;6 cl, 10 dwg, 4 tbl, 9 ex