FUSION PROTEINS FOR THE OUTER MEMBRANE VESICLE (OMV) DELIVERY OF HETEROLOGOUS POLYPEPTIDES AND IMMUNOGENIC COMPOSITIONS THEREOF

摘要

There are disclosed fusion proteins comprising the bacterial protein FhuD2 and one or more copies of a heterologous polypeptide, polynucleotides and expression vectors encoding the fusion proteins and bacterial outer membrane vesicles containing them. Other aspects of the invention regard immunogenic compositions comprising the outer membrane vesicles and their use in the prevention or treatment of tumors.