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APPLICATION OF CLOFOCTOL FOR MANUFACTURING PHARMACEUTICAL PRODUCT FOR TREATING HUMAN NEUROGLIOMA
APPLICATION OF CLOFOCTOL FOR MANUFACTURING PHARMACEUTICAL PRODUCT FOR TREATING HUMAN NEUROGLIOMA
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机译:氯氟酚在制造治疗人类神经胶质瘤的药物产品中的应用
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摘要
The present invention discloses an application of clofoctol for manufacturing a pharmaceutical product for treating human neuroglioma. The clofoctol is a pharmaceutical product for treating an upper respiratory tract infection. The clofoctol exerts a significant and specific inhibition of a glioma stem cell activity relative to a human neuroglioma cell or a normal human astroglia, human embryonic kidney cell, and human neural stem cell. A glioma stem cell treated with the clofoctol exhibited significantly reduced self-renewal, tumorsphere formation, and in vivo tumor formation in a nude rat. In vivo experiments using a zebrafish glioma transplantation model and a nude rat glioma transplantation model provided in vivo verification for the therapeutic efficacy of the pharmaceutical product against glioma. The invention specifically found that a clofoctol for treating an upper respiratory tract infection can achieve targeted inhibition of the glioma stem cell, and can thus be used in preparing a pharmaceutical product for treating human neuroglioma. The invention provides a novel therapeutic pharmaceutical product for treating human neuroglioma.
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