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Method of Determining Risk of Development and / or Severation of Nonalcoholic Fatty Liver Disease and / or Nonalcoholic Steatohepatitis and Oligonucleotide Kit for the Determination

机译:测定非酒精性脂肪性肝病和/或非酒精性脂肪性肝炎发生和/或消失的风险的方法和寡核苷酸试剂盒

摘要

PROBLEM TO BE SOLVED: To provide determination methods for the risk of onset and/or severity of nonalcoholic fatty liver disease (NAFLD) and/or nonalcoholic steatohepatitis (NASH), as well as to provide oligonucleotide kits for the determination thereof.SOLUTION: A determination method for the risk of onset and/or severity of NAFLD/NASH comprises detecting a single-nucleotide polymorphism represented by the rs number registered in National Center for Biotechnology Information SNP database, the single-nucleotide polymorphism being one or more single-nucleotide polymorphisms selected from rs1047840, rs2229629, rs35929428, rs2229207, and rs111988437, and/or one or more single-nucleotide polymorphisms in linkage disequilibrium with the single-nucleotide polymorphism.SELECTED DRAWING: Figure 1
机译:解决的问题:提供非酒精性脂肪肝疾病(NAFLD)和/或非酒精性脂肪性肝炎(NASH)发作和/或严重程度的测定方法,并提供用于测定其的寡核苷酸试剂盒。确定NAFLD / NASH发作和/或严重程度的风险的方法包括检测由在国家生物技术信息中心SNP数据库中注册的rs编号表示的单核苷酸多态性,该单核苷酸多态性是一个或多个单核苷酸多态性选自rs1047840,rs2229629,rs35929428,rs2229207和rs111988437和/或一个或多个具有单核苷酸多态性的连锁不平衡中的单核苷酸多态性。图1

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