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Transgenic mouse expressing kidney-specific human TGF-beta1, and biomarker for tissue fibrosis mouse model
Transgenic mouse expressing kidney-specific human TGF-beta1, and biomarker for tissue fibrosis mouse model
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机译:表达肾脏特异性人类TGF-beta1的转基因小鼠和组织纤维化小鼠模型的生物标志物
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摘要
A transgenic mouse has a genome that includes the entire gene region of human transforming growth factor beta-1 (human TGFβ1) located downstream of a mouse Podocin promoter such that expression of the human TGFβ1 is controlled by the mouse Podocin promoter. The human TGFβ1 contains 7 exons and 6 introns, the human TGFβ1 is expressed in a kidney of the mouse as non-active TGFβ1 and becomes active TGFβ1 extracellularly, and the transgenic mouse spontaneously develops renal fibrosis.
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