bioreactor for modulating lymphocytes and suppressing self-reactive t cells, system for inhibiting an autoimmune disorder, and methods for inhibiting an autoimmune t-cell autoimmune disorder, and for activating regulatory t-cells

摘要

'' bioreactor to modulate lymphocytes and suppress self-reactive t cells, system for inhibiting an autoimmune disorder, and methods for inhibiting an autoimmune t-cell autoimmune disorder, and for active regulatory t-cells '' methods and mechanisms are disclosed co-cultivating stem cells with mononuclear cells and / or lymphocytes to modulate their function. The invention also discloses the use of stem cells to educate auto-reactive immune cells as a mechanism for the treatment of autoimmune diseases and disorders related to immune disorder, such as diabetes. In one aspect of the invention, biorectors are disclosed to modulate lymphocytes and suppress self-reactive t cells. Bioreactors may include a chamber having at least one positively charged and / or hydrophobic substrate surface, a population of stem cells attached to the substrate surface, an inlet conduit for introducing lymphocytes into the chamber and an outlet conduit for extracting the substrates. treated lymphocytes following coculture with stem cells.