ANTIRETROVIRAL FORMULATION IN POLYMERIC NANOPARTICLES FOR THE TREATMENT OF HIV / AIDS AND THEIR TOXICITY TESTS, IN VITRO PERMEABILITY AND IN VIVO BIODISTRIBUTION

摘要

This invention concerns a pharmaceutical formulation capable of treating and controlling human immunodeficiency virus (HIV),Causes acquired immune deficiency syndrome (AIDS). The formulation is composed primarily of polyaprolactone polymeric nanoparticles and an antiretroviral agent. The invention also refers to polyaprolactone polymer nanoparticles containing an antiretroviral agent that does not present lymphocyte toxicity, has approximately twice the permeability when compared to a conventional formulation and has plasm A levels. Elevated and constant levels after oral administration in mice.