COMBINATION THERAPY FOR LOWER URINARY TRACT DISORDERS WITH A2O LEAGERS AND NSAIDS

摘要

α2α calcium channel subunit binder (α2d), non-steroidal antiinflammatory drug (α1α) and uses are the administration to a mammal of a combination of compounds, of which at least one is α2α channel subunit binder. Calcium (a2d) and at least one is a non-steroidal anti-inflammatory drug (aine), which provides a surprising and potent inhibition of the micturition reflex, superior to the inhibition obtained by treatment with an a2d or aine ligand alone. combinations of α2d and aines ligands are thus useful for the treatment of lower urinary tract disorders and symptoms thereof. Preferred α2d ligands are gabapentin and pregabalin. Preferred aines are celecoxib, diclofenac, diflunisal, flurbiprofen, naproxen, nimesulide or