RECOMBINANT CARBOXYDOTROPHIC ACETOGENIC MICROORGANISM, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THE PRODUCTION OF PRODUCTS USING SAME

摘要

The invention relates to a recombinant carboxydotrophic acetogenic microorganism producing a reduced amount or no 2,3-butanediol upon fermentation of a substrate comprising carbon monoxide, the microorganism comprising at least one genetic modification which disrupts the expression or activity of enzyme capable of converting pyruvate to acetolactate, enzyme capable of converting acetolactate to acetoin and/or enzyme capable of converting acetoin to 2,3-butanediol, thus the 2,3-butanediol biosynthesis pathway is disrupted, the microorganism is produced from the parental microorganism selected from Clostridium autoethanogenum, Clostridium ljungdahlii, Clostridium ragsdalei and Clostridium coskatii. The invention also relates to a method for the production of such microorganism and a method for the production of products using the same.