首页> 外国专利> NOVEL VIBRIO PARAHAEMOLYTICUS BACTERIOPHAGE VIB-PAP-4 AND USE THEREOF IN INHIBITING PROLIFERATION OF VIBRIO PARAHAEMOLITICUS BACTERIA

NOVEL VIBRIO PARAHAEMOLYTICUS BACTERIOPHAGE VIB-PAP-4 AND USE THEREOF IN INHIBITING PROLIFERATION OF VIBRIO PARAHAEMOLITICUS BACTERIA

机译：新型弧菌副噬菌体 VIB-PAP-4及其在抑制增生ara> paraparamamoticus 细菌中的用途

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摘要

The present invention relates to Myoviridae bacteriophage Vib-PAP-4(Accession No. KCTC 13168BP), isolated from nature, which possesses ability to specifically kill Vibrio parahaemolyticus bacteria and has the genome represented by SEQ ID No: 1, and a method for preventing infection of Vibrio parahaemolyticus bacteria and treating infection of Vibrio parahaemolyticus baceteria, using a composition containing the bacteriophage as an effective ingredient. 展开▼

机译：本发明涉及自自然界分离的肌病毒科噬菌体Vib-PAP-4（登录号KCTC 13168BP），其具有特异性杀死副溶血弧菌的能力，并且具有由SEQ ID No：参照图1，使用含有噬菌体作为有效成分的组合物预防副溶血性弧菌细菌的感染和治疗副溶血性弧菌细菌的方法。展开▼

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公开/公告号WO2018117462A3

专利类型

公开/公告日2019-01-24

原文格式PDF

申请/专利权人 INTRON BIOTECHNOLOGY INC.;
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申请/专利号WO2017KR13765

发明设计人 YOON SEONG JUN;JUN SOO YOUN;KWON AN SUNG;SONG HYUN MIN;HWANG SOON HYE;KANG SANG HYEON;
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申请日2017-11-29

分类号C12N7;A61K35/76;

国家 WO

入库时间 2022-08-21 11:58:13

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1. 新型副溶血弧菌噬菌体VIB-PAP-4及其用于抑制副溶血弧菌细菌增殖的用途 [P] . 中国专利： CN110214181A . 2019-09-06

2. 新型副溶血弧菌噬菌体Vib-PAP-7及其用于抑制副溶血弧菌细菌增殖的用途 [P] . 中国专利： CN110709510A . 2020-01-17

3. NOVEL VIBRIO PARAHAEMOLYTICUS BACTERIOPHAGE VIB-PAP-4 AND USE THEREOF IN INHIBITING PROLIFERATION OF VIBRIO PARAHAEMOLITICUS BACTERIA [P] . 美国专利： US2019328803A1 . 2019-10-31

机译：新型弧菌副噬菌性噬菌体VIB-PAP-4及其在抑制增生弧菌中的用途

4. NOVEL VIBRIO PARAHAEMOLYTICUS BACTERIOPHAGE VIB-PAP-4 AND USE THEREOF IN INHIBITING PROLIFERATION OF VIBRIO PARAHAEMOLITICUS BACTERIA [P] . 世界知识产权组织专利： WO2018117462A2 . 2018-06-28

机译：新型弧菌副噬菌体 VIB-PAP-4及其在抑制增生ara> paraparamamoticus 细菌中的用途

5. NOVEL VIBRIO PARAHAEMOLYTICUS BACTERIOPHAGE VIB-PAP-7 AND USE OF SAME FOR INHIBITING VIBRIO PARAHAEMOLYTICUS BACTERIA PROLIFERATION [P] . US2021138005A1 . 2021-05-13

机译：新颖的vibrio parahaemolyticus噬菌体vib-pAP-7以及用于抑制vibrio parahaemolyticus细菌增殖的方法

1. Survival and proliferation of the lysogenic bacteriophage CTXΦ in Vibrio cholerae [J] . Fenxia, Fan, Biao, 中国病毒学：英文版 . 2015,第001期

2. Microbial community changes in the digestive tract of the clam Meretrix petechialis in response to Vibrio parahaemolyticus challenge [J] . Hongxia WANG, Xin YUE, Jiajia YU, 中国海洋湖沼学报（英文版） . 2021,第001期

3. Rapid Proliferation of Vibrio parahaemolyticus, Vibrio vulnificus, and Vibrio cholerae during Freshwater Flash Floods in French Mediterranean Coastal Lagoons [J] . Kevin Esteves, Dominique Hervio-Heath, Thomas Mosser, Applied and Environmental Microbiology . 2015,第21期

4. Rapid Proliferation of Vibrio parahaemolyticus, Vibrio vulnificus, and Vibrio cholerae during Freshwater Flash Floods in French Mediterranean Coastal Lagoons [J] . Kevin Esteves, Dominique Hervio-Heath, Thomas Mosser, Applied Microbiology . 2015,第21期

5. Bacteriophages Against Pathogenic Vibrios in Delaware Bay Oysters (Crassostrea virginica) During a Period of High Levels of Pathogenic Vibrio parahaemolyticus [J] . Richards Gary P., Chintapenta Lathadevi K., Watson Michael A., Food and Environmental Virology . 2019,第2期

6. Distribution of the two novel vf33-like filamentous bacteriophage among the pandemic strains of vibrio parahaemolyticus O3:K6 and related strains [C] . Obin Chang, Midori Ogawa, Hiroshi Miyamoto, 7th China-Japan International Congress of Microbiology Shanghai Symposium-2000 4-6 August 2000 Shanghai . 2000

7. Inhibiting Listeria monocytogenes, Vibrio parahaemolyticus and Morganella morganii with Aqueous Methanol Extracts of Punica granatum and Galla chinensis [D] . Wu, Jian. 2014

8. Incidence of Vibrio parahaemolyticus Bacteriophages and Other Vibrio Bacteriophages in Marine Samples [O] . John A. Baross, John Liston, Richard Y. Morita 1978

9. Rapid proliferation of Vibrio parahaemolyticus, Vibrio vulnificus and Vibrio cholerae during freshwater flash floods in French Mediterranean coastal lagoons [O] . Esteves, Kevin, Hervio-heath, Dominique, Mosser, Thomas, 2015

1. Survival and proliferation of the lysogenic bacteriophage CTXφ in Vibrio cholerae [J] . Fenxia Fan ,Biao Kan . 中国病毒学 . 2015,第001期

2. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004）（P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期

3. Spontaneous small bowel perforation secondary to Vibrio parahaemolyticus infection:A case report [J] . Shih-Chun Chien ,Chih-Chung Chang ,Shih-Chao Chien . 世界临床病例杂志 . 2021,第005期

4. 新型镇痛药COX-2抑制剂的临床新用途 [C] . 蒋宗滨 . 第六次全国麻醉学与复苏进展学术交流会 . 2007

5. 噬菌体展示筛选花生主要过敏原Ara h 3的特异性纳抗体和Fag t 6：荞麦种子中的一种新型主要过敏原 [A] . 陈凤 . 2021