NEUROTOXICITY EVALUATION MODEL SYSTEM USING DISEASED IPS CELL, AND USE THEREOF

摘要

The present invention provides a method for evaluating the neurotoxicity of a compound to a human body, said method including steps (1) to (3): (1) bringing a nerve cell (CMT-N) differentiated and induced from an iPS cell from a human body suffering from CMT into contact with each of test compounds; (2) assessing at least one phenotype selected from the group consisting of (a) the state of a mitochondrion in a neurite, (b) an ATP level in a neurite and (c) an MFN2 protein level in the nerve cell; and (3) selecting a test compound that worsens the phenotype in (2) compared with a control in which the nerve cell is not contacted with any one of the test compounds as a compound capable of causing neurotoxicity to a human body.