Induced pluripotent stem cells for modeling and cell therapy of Parkinson＇s disease

摘要

Neurodegenerative disorders include a variety of hereditary or sporadic diseases involving the chronic,progressive loss on neural tissue.Parkinson’s disease(PD)is the second most common neurodegenerative disease,affecting more than 6 million people worldwide(Wan et al.,2015).Degeneration of nigrostriatal dopamine(DA)neurons is the main pathology in PD,although other dopaminergic and