METHOD FOR ESTABLISHING SERUM GLYCOPROTEIN GLYCOME PROFILE MODEL OF CHRONIC HEPATITIS AND LIVER DAMAGE

摘要

Disclosed is a method for establishing a serum glycoprotein glycome profile model of chronic hepatitis and liver damage. The method uses a G-Test detection method to detect a serum glycoprotein glycome profile, establishes a glycome profile model, with liver damage patients and normal controls having a significant difference therebetween, screens for NG1A2F, the expression thereof being significantly different between the liver damage group and the normal control group, and can detect the degree of liver damage of persons to be tested by comparing the peak value of the singlet NG1A2F in the N-glycome profile of the serum of the persons to be tested with that thereof in the established profile model. The method can enable many patients suffering from chronic hepatitis and liver damage to undergo routine, non-invasive detection, and monitors the occurrence and disease progression of chronic hepatitis and liver damage in a timely manner.