首页> 外国专利> KIT FOR TRACKING AND DIAGNOSING DEGREE OF PROGRESSIVE CHRONIC HEPATITIS AND LIVER FIBROSIS BY MEASURING ASIALO (alpha)1-ACID GLYCOPROTEIN AS HEPATOCELLULAR INJURY MARKER AND USE THEREOF

KIT FOR TRACKING AND DIAGNOSING DEGREE OF PROGRESSIVE CHRONIC HEPATITIS AND LIVER FIBROSIS BY MEASURING ASIALO (alpha)1-ACID GLYCOPROTEIN AS HEPATOCELLULAR INJURY MARKER AND USE THEREOF

机译:通过测量Asialo(α)1-酸糖蛋白作为肝细胞损伤标记的肝细胞损伤和用途来跟踪和诊断慢性慢性肝炎和肝纤维化的套件

摘要

Exemplary embodiments of the present invention relate to rapidly and easily test initial liver disease and more particularly to a monoclonal antibody for α1-acid glycoprotein, a diagnosis kit for tracking progressive chronic hepatitis and liver fibrosis in an initial phase of liver disease by measuring the concentration of asialo-α1-acid glycoprotein (AsAGP) as a hepatocyte injury marker in a sample using the antibody, and a use thereof.;Further, embodiments of the present invention provide a kit for specifically determining the degree of progressive chronic hepatitis and hepatic fibrosis from a blood sample and an immunochromatography strip, comprising a HRP-RCA II (Ricinus communis agglutinin II) conjugate or a Gold-RCA II conjugate specifically binding to asialo α-1 acid glycoprotein.
机译:本发明的示例性实施方案涉及快速且易于测试初始肝病,更具体地涉及α1-酸糖蛋白的单克隆抗体,通过测量浓度来跟踪肝病初始阶段的逐步慢性肝炎和肝纤维化的诊断试剂术asialo-α1-酸糖蛋白(Asagp)作为使用抗体的样品中的肝细胞损伤标记物,以及其用途。此外,本发明的实施方案提供了一种特异性地确定渐进性慢性肝炎和肝纤维化程度的试剂盒从血液样品和免疫层析条带,包含HRP-RCA II(Ricinus Communis alglutinin II)缀合物或与Asialoα-1酸糖蛋白特异性结合的金 - RCA II缀合物。

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