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POLYMER-LIPID HYBRID NANOPARTICLES OF CAPECITABINE UTILIZING MICROMIXING AND CAPECITABINE AMPHIPHILIC PROPERTIES
POLYMER-LIPID HYBRID NANOPARTICLES OF CAPECITABINE UTILIZING MICROMIXING AND CAPECITABINE AMPHIPHILIC PROPERTIES
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机译:卡西他滨的聚合物-脂质混合纳米微粒利用微粉化和卡西他滨的两亲性质
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摘要
The disclosure includes compositions and methods of making a nanoparticle composition comprising a phospholipids core comprising one or more lipids and one or more active agents, and at least one layer of one or more polymers on the surface of the phospholipids core. More specifically, the disclosure relates to the use of capecitabine (N4-pentyloxycarbonyl-5-deoxy-5-fluoro-cytidine, CAP) within such a lipid-polymer nanoparticle formulation for optimizing pharmaceutical properties of capecitabine for the treatment of cancer.
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