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METHODS FOR HIGH-RESOLUTION GENOME-WIDE FUNCTIONAL DISSECTION OF TRANSCRIPTIONAL REGULATORY REGIONS
METHODS FOR HIGH-RESOLUTION GENOME-WIDE FUNCTIONAL DISSECTION OF TRANSCRIPTIONAL REGULATORY REGIONS
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机译:转录调控区高分辨率基因组功能解析的方法
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摘要
Embodiments disclosed herein provide a general, scalable, high-throughput, and high-resolution approach for experimental dissection of regulatory regions and driver nucleotides in the context of human biology and disease. Applicants present HiDRA, a novel high-resolution global screen for transcriptional regulatory activity in accessible chromatin regions, enabling high-efficiency, high-throughput, and high-resolution inference of regulatory activity.
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