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ENHANCED DIFFERENTIATION AND MATURATION OF PLURIPOTENT STEM CELL-DERIVED MYOGENIC CELLS
ENHANCED DIFFERENTIATION AND MATURATION OF PLURIPOTENT STEM CELL-DERIVED MYOGENIC CELLS
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机译:多能干细胞衍生的成肌细胞的增强分化和成熟
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摘要
A method to increase the efficiency of myotube generation and maturation from pluripotent stem cells comprising: (a) differentiating pluripotent stem cells to myogenic progenitors; and (b) terminally differentiating said myogenic progenitors from (a) into myotubes in the presence of at least one gamma secretase inhibitor, wherein myotube generation is increased in the presence of at least one gamma secretase inhibitor, as compared to differentiation in the absence of gamma secretase inhibitors.
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