FABRICATION OF PHAGE NANOBIOPARTICLES AGAINST BURN WOUND METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) INFECTIONS

摘要

Despite advances in the field of control and treatment of burn wounds but infection is the main cause of mortality in burn patients. Control and treatment of infected wound are one of the main problems due to increased strains MDR (multi drug resistance) as methicillin-resistant staphylococcal aureus (MRSA). According to increased multidrug resistance (MDR) and the return of infections need a new product to treatment of infection. Lytic bacteriophages and their products as endolysin are suggested. In order to optimal using of bacteriophages in the field of nanomedicine the phage display technique is used. The results showed phage nanobioparticles have lytic activity on MRSA In vitro, and phage nanobioparticle gel has lytic activity on MRSA In vivo. After 30 days was observed reepithelization, scar formation, fibroblast maturation, collagen deposition, granulation tissue, neovascularization in the infected group and treated with phage nanobioparticle gel.