DNA 1 Synergistic anti-tumoral efficacy enhancement of DNA topoisomerase 1 inhibitor by methylenebis and its related compounds through the regulation of autophagy

摘要

The present invention relates to a method for enhancing anticancer efficacy of a DNA topoisomerase 1 inhibitor by using an autophagy control mechanism of methylenebis and related compounds, and more particularly, to prevent cancer comprising a compound represented by Formula 1 as an active ingredient. Or to a therapeutic composition. The method of the present invention can be usefully used to treat cancer by reducing the resistance and side effects of anticancer drugs by improving the anticancer effects of the inhibitors of DNA topoisomerase 1 used clinically.