ANALOGUES OF BICALUTAMIDE OR (S)-BICALUTAMIDE AS EXOCYTOSIS ACTIVATING COMPOUNDS FOR USE IN TREATMENT OF LYSOSOMAL STORAGE DISORDER OR GLYCOGENOSIS

摘要

FIELD: medicine.;SUBSTANCE: invention relates to use of compound (S)-bicalutamide and/or structural analogue, which are collectively determined by general formula (II), as well as their pharmaceutically acceptable salts, hydrates and/or solvates for preventing clinical symptoms and/or treatment of diseases and/or disorders of lysosomal accumulation and/or glycogenosis. In formula (II) R₁ is halogen (F, Cl, Br or I), R₄ is a trifluoromethyl group (-CF₃), R₅ is a nitrile (-CN) group, X is a thioether (S), a sulphoxide (SO), a sulphone (SO₂) or oxygen (O). (II).;EFFECT: invention also relates to use of said compounds in diagnosing diseases and/or disorders of lysosomal accumulation and/or glycogenosis and using a pharmaceutical composition containing said compounds.;11 cl, 1 dwg, 5 tbl, 6 ex