High-throughput screening of combinatorial libraries using on-chip optical detection and mass spectrometric sequencing

摘要

A method for making an array of microparticles of a combinatorial one-bead-one compound library on a base plate, comprising: - pressing a screen onto the base plate, wherein a mesh of the screen is selected such that each mesh contains exactly one microparticle of the combinatorial one -Bead One Compound library can penetrate into the sieve, - Applying the microparticles of the combinatorial One Bead One compound library on the sieve so that the applied microparticles are entered into the mesh of the sieve, - Fixing in the Meshes of the sieve incorporated microparticles of the combinatorial One Bead One Compound library on the base plate; and- removing the sieve from the base plate.