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METHOD FOR ASSESSING LYMPH NODE METASTATIC POTENTIAL OF ENDOMETRIAL CANCER

机译:子宫内膜癌淋巴结转移潜力的评估方法

摘要

Provided is an approach for discriminating endometrial cancer at a molecular level between endometrial cancer with lymph node metastasis and that without metastasis. A method for assessing lymph node metastasis or lymph node metastatic potential of endometrial cancer, comprising the step of measuring an expression level of an expression product of at least one DNA comprising a transcription start site in a biological sample derived from a cancer tissue isolated from an endometrial cancer patient, wherein the DNA comprises a base at an arbitrary position in the transcription start site in any of nucleotide sequences represented by SEQ ID NOs: 1 to 277 and at least one or more bases located immediately downstream thereof, and the transcription start site is a region wherein both ends thereof are defined by the first base in any of the nucleotide sequences represented by SEQ ID NOs: 1 to 277 and the 101st base counted from the 3' end.
机译:提供了一种在分子水平上区分具有淋巴结转移的子宫内膜癌与没有转移的子宫内膜癌的方法。一种评估子宫内膜癌的淋巴结转移或淋巴结转移潜能的方法,其包括以下步骤:测量至少一种DNA的表达产物的表达水平,所述DNA包含从分离自癌的癌组织的生物样品中的转录起始位点。子宫内膜癌患者,其中所述DNA包含在由SEQ ID NO:1至277表示的任何核苷酸序列中的转录起始位点中任意位置的碱基和紧邻其下游的至少一个或多个碱基,以及所述转录起始位点SEQ ID NO:1是其中其两端由SEQ ID NO:1至277表示的任何核苷酸序列中的第一个碱基和从3'端开始计数的第101个碱基定义的区域。

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