IMMUNOLOGICAL BIOMARKER FOR PREDICTING CLINICAL EFFECT OF CANCER IMMUNOTHERAPY

摘要

To provide an immunological biomarker for predicting clinical effects of a cancer immunotherapy.SOLUTION: This relates to prediction of responsiveness against a cancer immunotherapy of a subject based on a T-cell composition of the subject, and a method of a medical treatment using the cancer immunotherapy based on the prediction thereof. Moreover, the present invention provides a method for improving or maintaining the responsiveness against the cancer immunotherapy of the subject. Determining relative values for, a CD4T-cell subpopulation, a dendritic cell subpopulation, and/or a CD8T-cell subpopulation, that correlate to dendritic cell stimulation in anti-tumor immunity responsiveness within samples derived from the subject, predicts the responsiveness against the cancer immunotherapy. In addition, a composition for treating or preventing a cancer including cells such as a CD62 LCD4T-cell and the like is provided.SELECTED DRAWING: Figure 22