Clinical predictive values of biomarker levels in non-small cell lung cancer

摘要

Objective To evaluate the predictive value of serum levels of PD-1,IL-17,and IL-21 in patients with nonsmall cell lung cancer.Methods Serum levels of PD-1,IL-17,and IL-21 were analyzed by ELISA in 45 patients with non-small cell lung cancer（NSCLC） and 30 healthy individuals.Results Serum PD-1,IL-17,and IL-21 levels were significantly different between preoperative patients with NSCLC and the control group（P ＜ 0.01）,while there was no significant differences between the postoperative patients and the control group（P ＞ 0.05）.Comparison of serum PD-1,IL-17,and IL-21 levels of patients with NSCLC before and after the operation revealed a decrease in PD-1 and IL-17 levels and an increase in IL-21 levels.The serum levels of PD-1 and IL-17 were higher in patients with advanced staged disease than in those with early stage cancer（P ＜ 0.05）,while IL-21 levels were lower at the advanced stages（P ＜ 0.05）.Conclusion In patients with NSCLC,serum levels of PD-1,IL-17,and IL-21 changed considering the surgical operation and the course of the disease.Screening these biomarker levels might provide a helpful index for treatment and prognosis