wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, and wherein R3 is hydrogen, an alkyl group having from one to ten carbon atoms, or a halogen. Preferably the compound of Formula II includes wherein R3 is a halogen, and most preferably wherein the halogen is chlorine. Methods of treating a patient with cancer with these compounds are also provided."/>
Cyclopentadpyrimidines and substituted cyclopentadpyrimidines as antitubulin and microtubule targeting agents, monocyclic pyrimidines as tubulin inhibitors, and pyrrolopyrimidines as targeted antifolates and tubulin and multiple receptor tyrosine kinase inhibition and antitumor agents
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Cyclopentadpyrimidines and substituted cyclopentadpyrimidines as antitubulin and microtubule targeting agents, monocyclic pyrimidines as tubulin inhibitors, and pyrrolopyrimidines as targeted antifolates and tubulin and multiple receptor tyrosine kinase inhibition and antitumor agents
Cyclopentadpyrimidines and substituted cyclopentadpyrimidines as antitubulin and microtubule targeting agents, monocyclic pyrimidines as tubulin inhibitors, and pyrrolopyrimidines as targeted antifolates and tubulin and multiple receptor tyrosine kinase inhibition and antitumor agents
The present invention provides a compound of Formula II, and salts thereof, and a pharmaceutical composition comprising a compound of Formula II:; wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, and wherein R3 is hydrogen, an alkyl group having from one to ten carbon atoms, or a halogen. Preferably the compound of Formula II includes wherein R3 is a halogen, and most preferably wherein the halogen is chlorine. Methods of treating a patient with cancer with these compounds are also provided.
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机译：本发明提供式II化合物及其盐，以及包含式II化合物的药物组合物： 其中R是氢或具有1至10个碳原子的烷基，且其中R Sub 3是氢，具有1至10个碳原子的烷基或卤素。优选地，式II的化合物包括其中R 3 是卤素，并且最优选地其中卤素是氯。还提供了用这些化合物治疗癌症患者的方法。
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