Small Molecule Enhancers of Paneth Cell Function and Differentiation

摘要

Leucine-rich repeat-containing G-protein coupled receptor 5-positive (LGR5⁺) intestinal cells are contacted with an inhibitor of exportin 1 (XPO1), thereby producing functionally differentiated intestinal cells. The LGR5⁺ cells can also be contacted with a Wnt agonist. The LGR5⁺ cells can also be contacted with a Notch inhibitor.