METHODS FOR INHIBITING NONALCOHOLIC STEATOHEPATITIS, NONALCOHOLIC FATTY LIVER DISEASE, AND/OR DE NOVO LIPOGENESIS

摘要

Provided herein are methods of treating nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD), and/or elevated de novo lipogenesis (DNL) by inhibiting caspase-2 activity or expression. Also disclosed are methods of screening for agents useful in such methods.