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CONTINUOUS EVOLUTION FOR STABILIZED PROTEINS
CONTINUOUS EVOLUTION FOR STABILIZED PROTEINS
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机译:稳定蛋白质的持续进化
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摘要
Some aspects of this disclosure relate to systems, apparatuses, compositions (e.g., isolated nucleic acids and vectors), and methods for improving the stability and/or solubility of proteins evolved using phage-assisted continuous evolution (PACE). In some embodiments, vectors described herein comprise nucleic acids encoding selection systems (e.g., positive and/or negative selection systems) that link expression of genes required for production of infectious phage particles to a desirable physiochemical (e.g., stability or solubility) and/or desired function of an evolved protein.
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