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Use of Upstream Open Reading Frame 45aa-uORF Nucleotide Sequence of PTEN Gene and Polypeptide Coded by 45aa-uORF
Use of Upstream Open Reading Frame 45aa-uORF Nucleotide Sequence of PTEN Gene and Polypeptide Coded by 45aa-uORF
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机译:PTEN基因上游开放阅读框45aa-uORF核苷酸序列和45aa-uORF编码多肽的使用
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摘要
Provided are an upstream Open Reading Frame (uORF) of a Phosphatase and Tensin homolog (PTEN) gene and a protein coded by the uORF. A potential ORF of 138 bases (45aa-uORF) in the 5′UTR of the PTEN, coding an oligopeptide of 45 amino acids (named PTEN-45aa) plays an important role in the development and progression progress of tumors. Further provided are a new diagnostic and therapeutic method and a drug screening platform for PTEN expression regulation related diseases, in particular neuroglioma. Also provided is a polypeptide for treatment of PTEN expression regulation related diseases.
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