rna molecule, chimeric ribonucleic acid (rna) molecule, isolated and / or exogenous polynucleotide, vector, host cell, polynucleotide, non-human organism, method, method for producing a non-human organism, extract of a host cell, composition, method to downwardly regulate the level and / or activity of a target RNA molecule in an organism, method to control a non-human organism, method to treat a disease in an individual, RNA molecule, use of an RNA molecule and kit

摘要

the present invention relates to innovative double-stranded rna (dsrna) structures and their use in gene silencing. in one embodiment, the dsrna comprises a structure in the shape of a double clamp (dumbbell). in another embodiment, a proportion of the sense and antisense filaments of the dsrna molecule contain ribonucleotides that have base pairing in a non-canonical base pair or have no base pairing.