CONJUGATE PRESENTING FACTOR VIII PRO-COAGULANT ACTIVITY, ITS USE, METHODS FOR ITS PREPARATION AND FOR SITE-DIRECT PEGUILATION OF A FACTOR VIII MUTEIN, AND PHARMACEUTICAL COMPOSITION

摘要

site-directed modification of fviii. this invention relates to factor viii muteins that are covalently linked, at a predefined site that is not an n-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. mutein conjugates retain pro-coagulant activity of eviii and have improved pharmacokinetic properties.