A METHOD OF DETERMINING THE PRESENCE OF CATALYTIC FACTOR VIII ALLO-ANTIBODIES CAPABLE OF DEGRADING FACTOR VIII IN A MAMMAL, AMINO ACID SEQUENCE INHIBITING ANY SITE IN FACTOR VIII MOLECULE BEING SENSIBLE TO CLEAVAGE BY ALLO-ANTIBODIES IN FACTOR VIII (VARIANTS), USE OF INHIBITOR OF CLEAVAGE OF FACTOR VIII TO NEUTRALIZE A CATALYTIC ACTIVITY OF ALLO-ANTIBODIES TO FACTOR VIII AND PHARMACEUTICAL COMPOSITION CONTAINING ALLO-ANTIBODIES BEING CAPABLE OF DEGRADING FACTOR VIII

摘要

The present invention relates to a method of determining the presence of catalytic anti-Factor VIII allo-antibodies capable of degrading Factor VIII in a mammal, and of characterising the cleavage sites in said Factor VIII molecule by said catalytic anti-Factor VIII allo-antibodies. It also relates to an anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor; and to a pharmaceutical composition comprising said catalytic anti-Factor VIII allo-antibodies which are capable of degrading Factor VIII, and further to a pharmaceutical composition comprising said anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor. Finally, the present invention relates to the application in therapeutics of said anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor, of a pharmaceutical composition comprising said catalytic anti-Factor VIII allo-antibodies which are capable of degrading Factor VIII and of a pharmaceutical composition comprising said anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor.