METHODS FOR TREATMENT OF UTERINE FEMALOMA AND ENDOMETRIOSIS

摘要

Methods of treating uterine fibroids, endometriosis, adenomyosis, or heavy menstrual bleeding in a subject, which include administering to the subject 10 to 60 mg per day of N- (4- (1- (2,6-difluorobenzyl) -5 - ((dimethylamino) methyl) -3- (6-methoxy-3-pyridazinyl) -2,4-dioxo-1,2,3,4-tetrahydrothieno [2,3-d] pyrimidin-6-yl) phenyl) -N'-methoxyurea and from 0.01 to 5 mg per day of a hormone replacement drug. The present disclosure provides methods for reducing menstrual bleeding in a subject, reducing the loss of bone mineral density in a subject caused by administering a GnRH antagonist to a subject, suppressing sex hormones in a subject, reducing vasomotor symptoms or hot flashes in a subject, and reducing symptoms of decreased libido in a subject having uterine fibroids, endometriosis or adenomyosis. Additionally provided are methods for maintaining a blood glucose profile, maintaining a lipid profile and / or maintaining bone mineral density in a premenopausal woman receiving treatment for one or more conditions or symptoms of endometriosis, adenomyosis, uterine fibroids or heavy menstrual bleeding; and methods of contraception and infertility treatment.