METHODS AND COMBINATIONS FOR MODULATING TOLERANCE TO OPIATES, OPIOIDS OR OPIOID ANALGESICS AND TREATING ACUTE AND CHRONIC PAIN

摘要

It provides methods for modulating tolerance to opiates, opioids or opioid analgesics and/or treating acute and chronic pain and/or decreasing opiate or opioid-induced side effects. Also provided is a combination comprising a therapeutically effective amount, or a sub-therapeutically effective amount, of opiate, opioid or opioid analgesic and a therapeutically effective amount of a cystine/glutamate antiporter system xc-inhibitor.