agent for suppressing an undesirable effect of an opioid analgesic, pain therapeutic and / or preventative agent, kit, pharmaceutical composition, methods for suppressing an undesirable effect of an opioid, and for treating and / or preventing pain, use of an compound and an opioid compound and combination

摘要

Provided are: an agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), which comprises a compound having adenosine A 2A receptor antagonistic activity or a pharmaceutically acceptable salt thereof as an active ingredient; the agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), wherein the undesirable effect of the opioid-type analgesic (opioid) is analgesic tolerance or constipation; the agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), wherein the undesirable effect of the opioid-type analgesic (opioid) is analgesic tolerance; and the like.