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Novel piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction

机译:新型哌嗪和哌啶衍生物,其合成及其在抑制VDAC寡聚,细胞凋亡和线粒体功能障碍中的用途

摘要

Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's disease.
机译:本文提供了哌嗪和哌啶衍生物,其合成及其在抑制VDAC寡聚,细胞凋亡和线粒体功能障碍中的用途。还提供了治疗与所述过程有关的疾病的方法,例如阿尔茨海默氏病。

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