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A METHOD FOR TREATING PULMONARY ARTERIAL HYPERTENSION AND ASSOCIATED PULMONARY ARTERIAL HYPERTENSION
A METHOD FOR TREATING PULMONARY ARTERIAL HYPERTENSION AND ASSOCIATED PULMONARY ARTERIAL HYPERTENSION
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机译:一种治疗肺动脉高压及相关肺动脉高压的方法
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摘要
There is a method of treating or preventing pulmonary arterial hypertension or associated pulmonary arterial hypertension in a patient. The method has the step of systemically administering to the patient a therapeutically effective amount of one or more compounds: (S)-ethyl 8-(2-amino-6-((R)-1-(5-chloro-[1,1'-biphenyl]-2- yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3- carboxylate or a pharmaceutically acceptable salt thereof, or (S) -8-(2-amino-6-((R)-1-(5-chloro-[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroeth- oxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid or a pharmaceutically acceptable salt thereof, or a combination of the foregoing. There is also a method of treating or preventing pulmonary arterial hypertension or associated pulmonary arterial hypertension in a patient by systemically administering a therapeutically effective amount of a TPH1 inhibitor from about 1 mg/kg/day to about 50 mg/ kg/day
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机译:有一种治疗或预防患者的肺动脉高压或相关的肺动脉高压的方法。该方法具有将治疗有效量的一种或多种化合物全身给药于患者的步骤:(S)-乙基8-(2-氨基-6-((R)-1-(5-氯-[1, 1'-联苯基] -2-(基)-2,2,2-三氟乙氧基)嘧啶-4-基)-2,8-二氮杂螺[4.5]癸烷-3-羧酸盐或其药学上可接受的盐,或(S) -8-(2-氨基-6-((R)-1-(5-氯-[1,1'-联苯] -2-基)-2,2,2-三氟乙氧基)嘧啶-4- yl)-2,8-二氮杂螺[4.5]癸烷-3-羧酸或其药学上可接受的盐,或上述的组合。还存在通过全身性给予约1mg / kg /天至约50mg / kg /天的治疗有效量的TPH1抑制剂来治疗或预防患者的肺动脉高压或相关的肺动脉高压的方法。
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