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WNT Indazole Inhibitors of The WNT Signal Pathway and Therapeutic Uses Thereof
WNT Indazole Inhibitors of The WNT Signal Pathway and Therapeutic Uses Thereof
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机译:WNT信号通路的WNT吲唑抑制剂及其治疗用途
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摘要
Indazole compounds for the treatment of various diseases or etiologies are disclosed. More specifically, the present invention mediates by treatment of disorders characterized by activation of Wnt pathway signaling (eg cancer, abnormal cell proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), Wnt pathway signaling Indazole compounds in genetic diseases and neurological conditions / disorders / diseases caused by the regulation of cell events, as well as by mutation or dysregulation of the Wnt pathway and / or mutation or dysregulation of one or more Wnt signaling components It relates to the use of analogues thereof. Also provided are methods of treating a Wnt-related disease state.
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