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- Antituberculosis peptides increasing toxicities of endogenous toxin and targeting toxin-antitoxin system of Mycobacterium tuberculosis and use thereof

机译：-增加结核分枝杆菌的内源性毒素的毒性并靶向毒素-抗毒素系统的抗结核肽及其用途

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摘要

The present invention relates to an antituberculosis peptide for increasing toxicity of Mycobacterium tuberculosis endogenous toxin and targeting a toxin-antitoxin system and a use thereof. Specifically, the antituberculosis peptide of the present invention increases RNA decomposition activity of a Mycobacterium tuberculosis toxin protein MazF4 and suppresses formation of MazEF4, a toxic-antitoxic complex, thereby inducing death of Mycobacterium tuberculosis. Therefore, the antituberculosis peptide can be usefully used as an antibiotic composition against the Mycobacterium tuberculosis.

机译：本发明涉及用于增加结核分枝杆菌内源毒素的毒性并靶向毒素-抗毒素系统的抗结核肽及其用途。具体地，本发明的抗结核肽增加了结核分枝杆菌毒素蛋白MazF4的RNA分解活性，并抑制了MazEF4（一种毒性-抗毒性复合物）的形成，从而诱导了结核分枝杆菌的死亡。因此，抗结核肽可以有效地用作抗结核分枝杆菌的抗生素组合物。

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公开/公告号KR20200009379A

专利类型
公开/公告日2020-01-30

原文格式PDF
申请/专利权人 SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION;
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申请/专利号KR20180083660
发明设计人 LEE BONG JIN;AHN DOHWAN;
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申请日2018-07-18
分类号C07K7/06;A61P31/06;
国家 KR
入库时间 2022-08-21 11:07:59

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