Trk C EWS-FLI1 Screening method inhibitors of interaction between Trk C protein and EWS-FLI1 protein

摘要

The present invention relates to a method for screening binding inhibitors of Trk C protein and EWS-FLI1 protein. The cancer treatment candidate screening method according to the present invention utilizes Trk C protein in Ewing sarcoma cells to induce Ewing sarcoma development and metastasis by stabilizing EWS-FLI1 protein through Trk C-EWS-FLI1 complex formation. And a method of screening a substance that reduces Trk C-EWS-FLI1 complex formation in Ewing sarcoma cells expressing EWS-FLI1 protein, thereby developing an anticancer substance that inhibits the development and metastasis of Ewing sarcoma.