Novel recombinant protein from bacteriophage having antibacterial activity to pathogenic gram-negative bacterium

摘要

The present invention relates to a bacteriophage-derived recombinant protein having antimicrobial activity against Gram-negative bacteria, and the bacteriophage-derived recombinant protein LysSS of the present invention exhibits killing ability to Gram-negative bacteria and can prevent or treat infectious diseases caused by bacteria, antibiotics, It can be widely used in disinfectants, food additives, feed additives and the like. In particular, the LysSS exhibits bacterial killing ability due to peptidoglycan decomposition using peptidoglycan, which is a cell wall component of bacteria, as a substrate, and peptidoglycan exists only in bacteria and not in humans or animals. LysSS of the present invention is safe and does not affect humans and animals, and can be applied to the pharmaceutical industry, food industry, biotechnology, etc., and effectively kills gram-negative bacteria at a target place or a target substance without problems of multi-drug antimicrobial resistance. There is an advantage to this.