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HIGH DOSE EXTENDED-RELEASE POTASSIUM CITRATE WAX MATRIX TABLET
HIGH DOSE EXTENDED-RELEASE POTASSIUM CITRATE WAX MATRIX TABLET
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机译:高剂量延缓释放柠檬酸钾蜡基片剂
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摘要
The present invention relates to a process for the preparation of high dose extended-release potassium citrate tablets comprising carnauba wax, wherein the tablets of the present invention are melt granulated or heat granulated carnauba wax. And a first portion consisting of potassium citrate and a second portion consisting of ungranulated potassium citrate. The high dose extended-release potassium citrate tablets of the present invention are robust to batch to batch solubility and friability, resulting in improved production capacity and reduced production costs.
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