PROCESS FOR THE PROPARATION OF CONTRAST MEDIUM IOMEPROL

摘要

The present invention relates to a method for preparing X-ray contrast agent iomeprole, more specifically 5-(2-hydroxyacetamido)-N, N'-bis(2, 3-dihydroxypropyl)-2 , 4, 6-triiodoisophthalamide (1b) by adding an inorganic base, an inorganic chloride, a solvent, etc. and performing an N-methylation reaction, ion exchange the inorganic salt generated during the reaction while reducing the existing manufacturing time The present invention relates to a method of manufacturing iomeprole which can be easily separated and removed without resin treatment and minimizes reaction impurities.