pyruvate kinase M2 PKM2 Biomarker PKM2 for early diagnosis of Renal disorders and their use

摘要

The present invention relates to a composition for early diagnosis of kidney disease comprising an agent for measuring the expression level of PKM2 (Pyruvate kinase M2) protein in urine, and the PKM2 protein of the present invention and its utilization technology are used for diabetes and drugs in urine. It can be useful for predicting and diagnosing premature kidney dysfunction and the degree of disease. Furthermore, it is possible to accurately determine whether kidney dysfunction is abnormal with high sensitivity and specificity. Since it can be effectively diagnosed in the clinical treatment process, it is widely used in various fields such as acute renal failure diagnosis due to drugs that can occur frequently in the clinical treatment process, preclinical toxicity experiments essential in the development of new drugs, and early detection of diabetic renal failure. Can be.