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MicroRNA在预防或治疗糖皮质激素引起的股骨头坏死中的应用

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摘要

本发明公开了microRNA在预防或治疗糖皮质激素引起的股骨头坏死中的应用。本发明公开了一种糖皮质激素引起的股骨头坏死早期诊断试剂盒，所述试剂盒包括用于检测miR‑16‑5p表达水平的试剂。本发明还公开了一种治疗糖皮质激素引起的股骨头坏死的药物，所述的药物包含miR‑16‑5p抑制剂。利用该miRNA检测股骨头坏死不仅能够快速有效的做到早期检测，而且为基因治疗、药物治疗等临床应用提供了治疗靶点和重要依据。

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公开/公告号CN106701922A

专利类型发明专利
公开/公告日2017-05-24

原文格式PDF
申请/专利权人边焱焱;
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申请/专利号CN201611102118.0
发明设计人边焱焱;翁习生;钱文伟;吴志宏;李红凌;王兴山;彭慧明;
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申请日2016-12-05
分类号C12Q1/68(20060101);A61K45/00(20060101);A61K31/7088(20060101);A61P19/08(20060101);
代理机构
代理人
地址 100730 北京市东城区东单三条5号
入库时间 2023-06-19 02:16:22

法律信息

法律状态公告日

法律状态信息

法律状态
2019-10-22

实质审查的生效 IPC(主分类):C12Q1/68 申请日:20161205

实质审查的生效
2017-05-24

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1. MicroRNA在预防或治疗糖皮质激素引起的股骨头坏死中的应用 [P] . 中国专利： CN106701922A . 2017-05-24
2. MicroRNA-100-5p在预防或治疗非创伤性股骨头坏死中的应用 [P] . 中国专利： CN113699229A . 2021-11-26
3. PEPTIDE, PEGUILLED PEPTIDE, COMPOSITION, PHARMACEUTICAL COMPOSITION, BOTTLE, DISINFECTION SOLUTION, METHOD FOR GROWTH INHIBITION, REPLICATION OR INFECTIVITY OF A MICRO-ORGANISM, METHOD FOR INHIBITION OF A BACTERIAL GROWTH, BACTERIAL GROWTH INHIBITION, TREATMENT OF A MICRO-ORGANISM INFECTION IN A SUBJECT AND PREVENTION OF A DISEASE IN A SUBJECT CAUSED BY OR ASSOCIATED WITH A MICRO-ORGANISM INFECTION, METHOD FOR INHIBITING BACTERIAL GROWTH IN A SUBJECT, A METHOD OF TREATMENT OF A BACTERIAL TREATMENT SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION, METHOD FOR PREVENTING A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION IN A SUBJECT, METHOD FOR INHIBITION OF VIRAL REPLICATION IN A SUBJECT TO A SUBJECT TO A SUBJECT ON A SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR THE PREVENTION OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR DISINFECTING AN INA [P] . BR112017028190A2 . 2018-09-04

机译：肽，规定的肽，成分，药物成分，瓶，消毒溶液，微生物的生长抑制，复制或感染的方法，细菌生长的抑制方法，细菌生长的抑制作用，治疗由微生物感染引起或与之有关的疾病的预防，疾病的抑制方法，一种细菌治疗方法的治疗和一种或多种细菌引起的疾病的治疗感染，预防由细菌感染引起的疾病或与之相关的疾病的方法，在受试者体内抑制病毒复制的方法以及对由细菌引起或与之相关的疾病的治疗在主题中，一种预防由对象中的病毒感染引起或与之相关的疾病的方法，一种用于对INA进行消毒的方法
4. "use of polyols, appropriate device for the treatment or prophylaxis of mucosal infection caused by yeast in mammals, process for therapeutic or prophylactic treatment of mammals suffering from or being subjected to an increased risk of infection of the mucosa caused by yeast, composition for use in this treatment, and, pharmaceutical preparation for use in the prophylactic or therapeutic systemic or topical treatment of mucosal infections caused by yeast. " [P] . BR9814721A . 2000-10-03

机译： “多元醇的用途，用于治疗或预防哺乳动物中酵母引起的粘膜感染的适当装置，用于治疗或预防由酵母引起的粘膜感染或增加感染风险的哺乳动物的方法，使用的组合物在这种治疗中，以及用于预防性或治疗性全身或局部治疗由酵母引起的粘膜感染的药物制剂。”
5. method for killing or inactivating microorganisms in mammalian tissue, antimicrobial composition, and method for decolonizing at least a portion of an individual's nasal cavities, anterior nostrils, and / or nasopharynx, for decolonizing at least a portion of an individual's esophageal cavity , to prevent and / or treat an affliction caused or aggravated by a microbial organism in the skin and / or mucosal membrane, to provide residual antimicrobial efficacy on a surface, to prevent and / or to treat an individual for a respiratory distress caused by a microbial infection, to treat a middle ear infection in an individual, to treat chronic sinusitis in an individual, to treat impetigo on an individual's skin, to treat and / or prevent an infection in mammalian tissue, to treat and / or prevent infection of the skin, mucosal tissue, and / or wound of an individual to provide residual antimicrobial efficacy on the skin, mucosal tissue, and / or in an individual's wound and to make an anti [P] . BRPI0514939A . 2008-07-01

机译：杀死或灭活哺乳动物组织中的微生物的方法，抗菌组合物，以及对至少一部分鼻腔，前鼻孔和/或鼻咽进行非殖民化的方法，以对至少一部分食道腔进行非殖民化，以防止和/或治疗由皮肤和/或粘膜中的微生物引起或加重的折磨，在表面上提供残留的抗菌功效，预防和/或治疗个体因微生物感染引起的呼吸窘迫，治疗个体中耳感染，治疗个体慢性鼻窦炎，治疗个体皮肤脓疱病，治疗和/或预防哺乳动物组织感染，治疗和/或预防皮肤，粘膜组织感染和/或个体的伤口，以在皮肤，粘膜组织和/或个体的伤口上提供残留的抗菌功效，并产生抗